基于联合违约概率的资产组合投资优化方法

投资组合的资产联合违约概率(joint,probability of default,JPoD)是一种有效的系统风险测度工具.基于JPoD分析,提出了一种新的资产组合选择优化方法,即通过计算资产池中每两种资产的JPoD值得到JPoD矩阵,利用遍历算法逐次筛选,得出具有最小系统风险的多资产组合.实证分析首先利用2014 2015年的上证综指和深证成指数据验证了JPoD方法的有效性;其次,分别利用中国股票市场数据和美国股票市场数据将所提出的资产组合选择方法与马科维茨均值-方差组合理论、随机组合方法进行比较,结果表明无论是在中国股票市场还是美国股票市场,JPoD方法都明显优于其他两种方法.     

Liver cell therapy: is this the end of the beginning?

The prevalence of liver diseases is increasing globally. Orthotopic liver transplantation is widely used to treat liver disease upon organ failure. The complexity of this procedure and finite numbers of healthy organ donors have prompted research into alternative therapeutic options to treat liver disease. This includes the transplantation of liver cells to promote regeneration. While successful, the routine supply of good quality human liver cells is limited. Therefore, renewable and scalable sources of these cells are sought. Liver progenitor and pluripotent stem cells offer potential cell sources that could be used clinically. This review discusses recent approaches in liver cell transplantation and requirements to improve the process, with the ultimate goal being efficient organ regeneration. We also discuss the potential off-target effects of cell-based therapies, and the advantages and drawbacks of current pre-clinical animal models used to study organ senescence, repopulation and regeneration.     

A new species of Phrynobatrachus (Amphibia: Anura: Phrynobatrachidae) from the Northern Mountains of Tanzania

ABSTRACT

Using integrative approaches, a new large-bodied species of Phrynobatrachus is described from a series of 48 specimens from the montane forests of the West Usambara and North Pare Mountains of Tanzania. The most distinguishing morphological feature separating Phrynobatrachus ambanguluensis sp. nov from similar species is the markedly overhanging and pointed upper jaw and snout. Mitochondrial 16S rRNA indicates that the new species differs from all other species with published sequence data by a minimum distance of 4.75% and is sister to P. krefftii, with which it has been confused in the past. The new species is known from two forest reserves and is of high conservation concern given these areas are highly impacted by anthropogenic change.

http://www.zoobank.org/urn:lsid:zoobank.org:pub:E0C82A87-47A5-426B-978D-96D27FA7A3B7     

基于偏振复用和反射式半导体光放大器的WDM-RoF-PON系统设计

基于偏振复用原理和反射式半导体光放大器RSOA(reflective semiconductor optical amplifier)的再调制特性,融入了光载无线RoF(radio over fiber)技术,设计了一种新型的可以实现多种信号混传的波分复用无源光网络WDM-PON(wavelength division multiplexing passive optical network)系统。在中心站,无线信号和有线信号同时调制到两个偏振态正交的光载波上,并耦合到标准单模光纤中传输。在基站,将两个偏振态正交的信号分离后,一方面可以探测得到四倍频毫米波信号和有线信号,另一方面还可以通过RSOA实现载波重用。通过Optisystem软件对该系统进行模拟仿真,得到了调制信号的光谱和接收端信号的眼图,分析了传输信号误码率与接收光功率的关系,结果表明,该系统传输性能良好。     

Glutamate transporters in the biology of malignant gliomas

Malignant gliomas are relentless tumors that offer a dismal clinical prognosis. They develop many biological advantages that allow them to grow and survive in the unique environment of the brain. The glutamate transporters system x _c ^? and excitatory amino acid transporters (EAAT) are emerging as key players in the biology and malignancy of these tumors. Gliomas manipulate glutamate transporter expression and function to alter glutamate homeostasis in the brain, which supports their own growth, invasion, and survival. As a consequence, malignant cells are able to quickly destroy and invade surrounding normal brain. Recent findings are painting a larger picture of these transporters in glioma biology, and as such are providing opportunities for clinical intervention for patients. This review will detail the current understanding of glutamate transporters in the biology of malignant gliomas and highlight some of the unique aspects of these tumors that make them so devastating and difficult to treat.